I spent the past 15 winter seasons, Jan-April in the Sea of Cortez, mostly on the Bahs side.
On the positive side: The people, the scenery and the food are great. Labor prices are very low compared to US.
Negative side: After May 1, the weather is too hot. From June to September expect a lot of days near 100F. If you don't have AC on your boat and can take that kind of heat you are more tolerant than I. The anchorages are mediocre if you are used to the kind of shelter provided in the PNW. You will rock and roll a lot in Mexico. Finally, moorage is very expensive compared to many places. If you are lucky enough to find a slip in LaPaz, you will pay at least $25US/ft/mo. And that is the cheaper monthly rate in the cheapest marina. In Cabo the daily rate is at least $10/ft/day. Yikes!!
Pacific mainland Mexico is mostly marinas because anchorages are few and far between. But you don't need a boat to visit Puerto Vallarta or any of the other Pacific seaside places. Drive there instead or take a bus.
My take is that Sea of Cortez is great for one or two winter seasons. After that you have seen the sights and made the tour. Many cruisers find the Sea of Cortez their favorite area but it is all relative to what other places you have experienced.
Ricard P