As a former runner (the key being "former" due to injuries) I agree with Murray. Take it easy, build slowly.
Two important suggestions. The first is to be able to differentiate between the pain that signals that you are doing damage, vs the normal muscular pain. I wasn't terribly good that that as I let my goal setting get in the way of common sense.
Second important suggestion is to not increase your base mileage too much, too fast. If you have heard of the "10% rule", ignore it. Instead, start with no more than 15-20 minutes several days/week. If that means you are only running 2 miles at a time, that is OK. Keep doing the same mileage for 3 weeks at a time. Then you can add some distance and again keep that for 3 weeks. Increase slowly but never add more to your weekly mileage than 1 mile for each days/week that you run. So if you run 3 days/week, never add more than 3 miles to your weekly mileage and hold it there for 3 weeks.
Take it easy on the NSAIDs. If you are taking it for pain, reconsider. If you are taking it to reduced inflammation, you likely aren't taking enough. Check with your doc.
Good luck!